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Mouse Krt6a Blocking Peptide(Center)

Synthetic peptide

Product Information
Primary Accession P50446
Other Accession Q9Z331, NP_032502.3
Additional Information
Gene ID 16687
Other Names Keratin, type II cytoskeletal 6A, Cytokeratin-6A, CK-6A, Keratin-6-alpha, mK6-alpha, Keratin-6A, K6A, Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Target/Specificity The synthetic peptide sequence is selected from aa 227-240 of MOUSE Krt6a
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Krt6a
Synonyms Ker2, Krt2-6, Krt2-6a, Krt6
Function Epidermis-specific type I keratin involved in wound healing (PubMed:10866680). Involved in the activation of follicular keratinocytes after wounding, while it does not play a major role in keratinocyte proliferation or migration (PubMed:10866680). Participates in the regulation of epithelial migration by inhibiting the activity of SRC during wound repair (PubMed:22529101).
Tissue Location Predominates in the adult trunk skin, tongue, trachea/esophagus and eye. In adult skin, localization is restricted to hair follicles, where it is localized predominantly in the outer root sheath.
Research Areas
Citations (0)

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Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77% of all forms found in epithelia.


Sehic, A., et al. Eur. J. Oral Sci. 117(2):93-104(2009)
Chen, J., et al. J. Invest. Dermatol. 128(2):270-279(2008)
Cui, C.Y., et al. Hum. Mol. Genet. 16(21):2583-2590(2007)
Gu, L.H., et al. J. Invest. Dermatol. 127(5):1061-1073(2007)
Kurek, D., et al. Development 134(2):261-272(2007)

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$ 80.00
Cat# BP19689c
Availability: 2 weeks
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