|Other Accession||NP_443083.1, NP_821074.1, NP_821075.1|
|Other Names||StAR-related lipid transfer protein 13, 46H232, Deleted in liver cancer 2 protein, DLC-2, Rho GTPase-activating protein, START domain-containing protein 13, StARD13, STARD13, DLC2, GT650|
|Target/Specificity||The synthetic peptide sequence is selected from aa 559-573 of HUMAN STARD13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells.|
|Cellular Location||Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet|
|Tissue Location||Ubiquitously expressed. Underexpressed in hepatocellular carcinoma cells and some breast cancer cell lines|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a sterile alpha motif domain in the N-terminus, an ATP/GTP-binding motif, a GTPase-activating protein domain, and a STAR-related lipid transfer domain in the C-terminus. The gene is located in a region of chromosome 13 that has loss of heterozygosity in hepatic cancer. At least three alternatively spliced transcript variants have been described for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Yasuno, K., et al. Nat. Genet. 42(5):420-425(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Xiaorong, L., et al. BMC Cancer 8, 205 (2008) :
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