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ASTN2 Blocking Peptide(N-term)

Synthetic peptide

     
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Product Information
Primary Accession O75129
Other Accession Q80Z10, NP_001171664.1, NP_054729.3, NP_937829.3, NP_937831.1
Additional Information
Gene ID 23245
Other Names Astrotactin-2, ASTN2, KIAA0634
Target/Specificity The synthetic peptide sequence is selected from aa 235-248 of HUMAN ASTN2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ASTN2
Synonyms KIAA0634
Function Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5- trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6).
Cellular Location Membrane {ECO:0000250|UniProtKB:Q80Z10}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80Z10} Perikaryon {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q80Z10}. Early endosome {ECO:0000250|UniProtKB:Q80Z10}. Late endosome {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasmic vesicle, clathrin- coated vesicle {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q80Z10}. Note=Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons Detected at the base of the leading process in migrating neurons {ECO:0000250|UniProtKB:Q80Z10}
Research Areas
Citations (0)

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Background

This gene encodes a protein that is expressed in the brain and may function in neuronal migration, based on functional studies of the related astrotactin 1 gene in human and mouse. A deletion at this locus has been associated with schizophrenia. Multiple transcript variants encoding different proteins have been found for this locus.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Adkins, D.E., et al. Mol. Psychiatry (2010) In press :
Lesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)
Vrijenhoek, T., et al. Am. J. Hum. Genet. 83(4):504-510(2008)

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$ 80.00
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Cat# BP19699a
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