IL17RE Blocking Peptide(N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8NFR9 |
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Other Accession | NP_001180309.1, NP_705613.1, NP_705616.2 |
Gene ID | 132014 |
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Other Names | Interleukin-17 receptor E, IL-17 receptor E, IL-17RE, IL17RE |
Target/Specificity | The synthetic peptide sequence is selected from aa 102-116 of HUMAN IL17RE |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | IL17RE |
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Function | Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors. |
Cellular Location | [Isoform 1]: Cell membrane; Single- pass type I membrane protein [Isoform 3]: Secreted. [Isoform 5]: Secreted. |
Tissue Location | Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein that shares limited similarity with the interleukin-17 receptor. The function of the encoded protein has not yet been determined. Alternatively spliced transcript variants have been described.
References
Eid, N.A., et al. Malar. J. 9, 119 (2010) :
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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