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TUBG1 Blocking Peptide(N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23258 |
|---|---|
| Other Accession | Q8VCK3, Q9NRH3, Q32KM1, P23330, P83888, P83887, Q0VCD2, NP_001061.2 |
| Gene ID | 7283 |
|---|---|
| Other Names | Tubulin gamma-1 chain, Gamma-1-tubulin, Gamma-tubulin complex component 1, GCP-1, TUBG1, TUBG |
| Target/Specificity | The synthetic peptide sequence is selected from aa 38-51 of HUMAN TUBG1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TUBG1 (HGNC:12417) |
|---|---|
| Synonyms | TUBG |
| Function | Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation. |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to mitotic spindle microtubules. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.
References
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010)
Alvarado-Kristensson, M., et al. Nat. Cell Biol. 11(9):1081-1092(2009)
Zhang, X., et al. J. Cell. Sci. 122 (PT 13), 2240-2251 (2009) :
Haren, L., et al. PLoS ONE 4 (6), E5976 (2009) :
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