EOMES Blocking Peptide(N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95936 |
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Other Accession | NP_005433.2 |
Gene ID | 8320 |
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Other Names | Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, EOMES, TBR2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 43-57 of HUMAN EOMES |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EOMES |
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Synonyms | TBR2 |
Function | Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. |
Cellular Location | Nucleus. |
Tissue Location | Expressed in CD8+ T-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.
References
Wang, H.T., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(1):31-34(2010)
Narayanan, S., et al. PLoS ONE 5 (5), E10636 (2010) :
D'Cruz, L.M., et al. Semin. Immunol. 21(2):92-98(2009)
Sessa, A., et al. Neuron 60(1):56-69(2008)
Araki, Y., et al. J. Immunol. 180(12):8102-8108(2008)
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