|Other Names||Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, EOMES, TBR2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 43-57 of HUMAN EOMES|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.|
|Tissue Location||Expressed in CD8+ T-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a conserved protein family that shares a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. A similiar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation.
Wang, H.T., et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 26(1):31-34(2010)
Narayanan, S., et al. PLoS ONE 5 (5), E10636 (2010) :
D'Cruz, L.M., et al. Semin. Immunol. 21(2):92-98(2009)
Sessa, A., et al. Neuron 60(1):56-69(2008)
Araki, Y., et al. J. Immunol. 180(12):8102-8108(2008)
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