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MKRN1 Blocking Peptide(Center)

Synthetic peptide

Product Information
Primary Accession Q9UHC7
Other Accession NP_038474.2
Additional Information
Gene ID 23608
Other Names E3 ubiquitin-protein ligase makorin-1, 632-, RING finger protein 61, MKRN1, RNF61
Target/Specificity The synthetic peptide sequence is selected from aa 199-213 of HUMAN MKRN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MKRN1
Synonyms RNF61
Function E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000 [PubMed 10843807]).


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ko, A., et al. J. Virol. 84(1):426-436(2010)
Lee, E.W., et al. EMBO J. 28(14):2100-2113(2009)
Shimada, H., et al. BMC Cancer 9, 232 (2009) :
Omwancha, J., et al. Endocrine 29(2):363-373(2006)

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$ 80.00
$ 99.00
Cat# BP19708c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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