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MKRN1 Blocking Peptide(Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UHC7 |
|---|---|
| Other Accession | NP_038474.2 |
| Gene ID | 23608 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase makorin-1, 632-, RING finger protein 61, MKRN1, RNF61 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 199-213 of HUMAN MKRN1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MKRN1 |
|---|---|
| Synonyms | RNF61 |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II- dependent transcription. |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Makorin ring finger protein-1 gene (MKRN1) is a highly transcribed, intron-containing source for a family of intronless mammalian genes encoding a novel class of zinc finger proteins. Phylogenetic analyses indicate that the MKRN1 gene is the ancestral founder of this gene family (Gray et al., 2000 [PubMed 10843807]).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ko, A., et al. J. Virol. 84(1):426-436(2010)
Lee, E.W., et al. EMBO J. 28(14):2100-2113(2009)
Shimada, H., et al. BMC Cancer 9, 232 (2009) :
Omwancha, J., et al. Endocrine 29(2):363-373(2006)
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