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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   XPC Blocking Peptide(N-term)   

XPC Blocking Peptide(N-term)

Synthetic peptide

Product Information
Primary Accession Q01831
Other Accession NP_001139241.1, NP_004619.3
Additional Information
Gene ID 7508
Other Names DNA repair protein complementing XP-C cells, Xeroderma pigmentosum group C-complementing protein, p125, XPC, XPCC
Target/Specificity The synthetic peptide sequence is selected from aa 169-183 of HUMAN XPC
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name XPC
Synonyms XPCC
Function Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA- binding activity.
Cellular Location Nucleus. Cytoplasm. Note=Omnipresent in the nucleus and consistently associates with and dissociates from DNA in the absence of DNA damage. Continuously shuttles between the cytoplasm and the nucleus, which is impeded by the presence of NER lesions
Research Areas
Citations (0)

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This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.


Gangwar, R., et al. J. Cancer Res. Clin. Oncol. (2009) In press :
Agalliu, I., et al. Cancer Causes Control (2009) In press :
Langie, S.A., et al. Br. J. Nutr., 1-12 (2009) In press :
Young, R.P., et al. Postgrad Med J 85(1008):515-524(2009)
Stern, M.C., et al. Cancer Res. 69(17):6857-6864(2009)

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$ 80.00
$ 99.00
Cat# BP19709a
(40 western blots)
Availability: 2 weeks
Bulk Size
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