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Mut-7 Antibody (N-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession P34607
Clone Names 6022406
Additional Information
Gene ID 176347
Other Names Exonuclease mut-7, 31--, Exonuclease 3'-5' domain-containing protein 3 homolog, mut-7
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1971a was selected from the N-term region of human Mut-7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name mut-7
Function Represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. Also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.
Research Areas
Citations (0)

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Background

Mut-7 represses the transposition of Tc1, Tc3, Tc4, and Tc5, perhaps by degrading transposon-specific messages. This protein also affects sperm development, sensitivity to RNAi of mainly germline expressed genes, silencing of some germline transgenes, X chromosome loss, and is required for cosuppression (functional silencing of chromosomal loci induced by transgenes) and for silencing induced by antisense RNA oligomers.

References

Topps, BB, et al. Nucleic Acids Res. 2005. 33(1):347-55.Ketting, R.F., et al. Cell 99:133-141(1999).Rizzon, C., et al. Genetics. 2003. 165(3):1127-35.

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$ 80.00
Cat# BP1971a
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