|Other Names||Uncharacterized protein F54F22, isoform a, F54F22/F54F23/F54F24|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1972a was selected from the N-term region of human Cezf. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
CEZF bears substantial homology ot the zinc finger and leucine zipper motifs of the human gene products AF10, MLLT6, and BR140. The functional domain of the zing finger motif, which is structurally different from previously described zinc finger motifs, is potentially disrupted in leukemia-associated chromosomal translocations. This zinc finger motif present in CEZF, called the leukemia-associatged protein (LAP) finger, is an important DNA-binding domain in this group of regulatory proteins, and may be involved in leukemogenesis.
Saha, V, et al. PNAS USA. 1995. 92(21): 9737锟?741.
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