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UGT2B4 Blocking Peptide(N-term)

Synthetic peptide

     
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Product Information
Primary Accession P06133
Other Accession NP_066962.2
Additional Information
Gene ID 7363
Other Names UDP-glucuronosyltransferase 2B4, UDPGT 2B4, HLUG25, Hyodeoxycholic acid-specific UDPGT, UDPGTh-1, UGT2B4, UGT2B11
Target/Specificity The synthetic peptide sequence is selected from aa 83-96 of HUMAN UGT2B4
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UGT2B4 (HGNC:12553)
Synonyms UGT2B11
Function UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:23288867). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240, PubMed:23288867). Catalyzes the glucuronidation of the endogenous estrogen hormones such as estradiol and estriol (PubMed:18719240, PubMed:23288867).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein
Research Areas
Citations (0)
citation

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Background

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme is active on polyhydroxylated estrogens (such as estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (such as 4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). It is capable of 6 alpha-hydroxyglucuronidation of hyodeoxycholic acid.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Levesque, E., et al. Pharmacogenet. Genomics 20(3):195-210(2010)
Yong, M., et al. Cancer Epidemiol. Biomarkers Prev. 19(2):537-546(2010)
Li, J., et al. Breast Cancer Res. 12 (2), R19 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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$ 277.78
Cat# BP19747a
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