|Other Names||Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, E-NPP 3, Phosphodiesterase I beta, PD-Ibeta, Phosphodiesterase I/nucleotide pyrophosphatase 3, CD203c, Alkaline phosphodiesterase I, Nucleotide pyrophosphatase, NPPase, ENPP3, PDNP3|
|Target/Specificity||The synthetic peptide sequence is selected from aa 829-843 of HUMAN ENPP3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves a variety of phosphodiester and phosphosulfate bonds including deoxynucleotides, nucleotide sugars, and NAD.|
|Cellular Location||Membrane; Single-pass type II membrane protein. Secreted Note=Located to the apical surface in intestinal and kidney epithelial cells. Located to the cell surface of basophils, and to the apical plasma membrane of bile duct cells. Secreted in serum, and in lumen of epithelial cells|
|Tissue Location||Expressed in bile ducts, prostate, uterus and colon. Exclusively expressed on basophils, mast cells and their progenitors.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq].
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ono, E., et al. J. Allergy Clin. Immunol. 125(2):483-489(2010)
Wolanczyk-Medrala, A., et al. Ann Agric Environ Med 16(2):301-304(2009)
Chirumbolo, S., et al. Inflamm. Res. 58(11):755-764(2009)
Ocmant, A., et al. J. Immunol. Methods 320 (1-2), 40-48 (2007) :
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