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CRYAA Blocking Peptide(Center)

Synthetic peptide

Product Information
Primary Accession P02489
Other Accession P24623, P02493, P02475, P24622, P02470, NP_000385.1, P02478, Q5ENZ0
Additional Information
Gene ID 102724652;1409
Other Names Alpha-crystallin A chain, Heat shock protein beta-4, HspB4, Alpha-crystallin A(1-172), Alpha-crystallin A(1-168), Alpha-crystallin A(1-162), CRYAA, CRYA1, HSPB4
Target/Specificity The synthetic peptide sequence is selected from aa 92-106 of HUMAN CRYAA
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms CRYA1, HSPB4
Function Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
Cellular Location Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles
Tissue Location Expressed in eye lens.
Research Areas
Citations (0)

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Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq].


Deng, M., et al. Biochim. Biophys. Acta 1802 (7-8), 621-631 (2010) :
Li, F.F., et al. Curr. Eye Res. 35(6):492-498(2010)
Pang, M., et al. Biochim. Biophys. Acta 1804(4):948-956(2010)
Bhagyalaxmi, S.G., et al. Oman J Ophthalmol 3(1):7-12(2010)
Singh, D., et al. Mol. Vis. 15, 2050-2060 (2009) :

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$ 80.00
$ 99.00
Cat# BP19751c
(40 western blots)
Availability: 2 weeks
Bulk Size
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