|Other Names||Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium- and chloride-dependent neurotransmitter transporter NTT73, Sodium-coupled branched-chain amino-acid transporter 1, Solute carrier family 6 member 15, Transporter v7-3, SLC6A15, B0AT2, NTT73, SBAT1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 4-18 of HUMAN SLC6A15|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||B0AT2, NTT73, SBAT1|
|Function||Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Almost exclusively expressed in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
SLC6A15 shows structural characteristics of an Na(+) and Cl(-)-dependent neurotransmitter transporter, including 12 transmembrane (TM) domains, intracellular N and C termini, and large extracellular loops containing multiple N-glycosylation sites (Farmer et al., 2000 [PubMed 11112352]).
Zaia, K.A., et al. J. Biol. Chem. 284(13):8439-8448(2009)
Broer, S. Physiol. Rev. 88(1):249-286(2008)
Broer, A., et al. Biochem. J. 393 (PT 1), 421-430 (2006) :
Takanaga, H., et al. Biochem. Biophys. Res. Commun. 337(3):892-900(2005)
Farmer, M.K., et al. Genomics 70(2):241-252(2000)
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