LRIG1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96JA1 |
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Other Accession | P70193, NP_056356.2 |
Gene ID | 26018 |
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Other Names | Leucine-rich repeats and immunoglobulin-like domains protein 1, LIG-1, LRIG1, LIG1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 816-829 of HUMAN LRIG1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | LRIG1 {ECO:0000303|PubMed:15282549} |
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Synonyms | LIG1 |
Function | Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Widely expressed.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LRIG1 act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Ye, F., et al. J. Neurooncol. 94(2):183-194(2009)
Ljuslinder, I., et al. Breast Cancer Res. 11 (3), 403 (2009) :
Miller, J.K., et al. Cancer Res. 68(20):8286-8294(2008)
Stutz, M.A., et al. Oncogene 27(43):5741-5752(2008)
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