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CRYM Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q14894
Other Accession NP_001879.1
Additional Information
Gene ID 1428
Other Names Ketimine reductase mu-crystallin, NADP-regulated thyroid-hormone-binding protein, CRYM, THBP
Target/Specificity The synthetic peptide sequence is selected from aa 169-183 of HUMAN CRYM
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms THBP
Function Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.
Cellular Location Cytoplasm.
Tissue Location Expressed in neural tissue, muscle and kidney.
Research Areas
Citations (0)

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Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene.


Martins-de-Souza, D., et al. J Psychiatr Res (2010) In press :
Al-Kafaji, G., et al. Biochem. Biophys. Res. Commun. 391(4):1585-1591(2010)
Malinowska, K., et al. Prostate 69(10):1109-1118(2009)
Martins-de-Souza, D., et al. J Psychiatr Res 43(11):978-986(2009)
Martins-de-Souza, D., et al. Eur Arch Psychiatry Clin Neurosci 259(3):151-163(2009)

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$ 80.00
$ 99.00
Cat# BP19781c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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