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PDE6H Blocking Peptide(Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q13956 |
|---|---|
| Other Accession | P09174, P18545, P04972, P61250, P61249, P22571, NP_006196.1 |
| Gene ID | 5149 |
|---|---|
| Other Names | Retinal cone rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase subunit gamma, GMP-PDE gamma, PDE6H |
| Target/Specificity | The synthetic peptide sequence is selected from aa 19-33 of HUMAN PDE6H |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | PDE6H |
|---|---|
| Function | Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G- protein-mediated phototransduction in vertebrate rods and cones. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Piri, N., et al. Ophthalmology 112(1):159-166(2005)
Kajimura, N., et al. J. Struct. Biol. 139(1):27-38(2002)
Shimizu-Matsumoto, A., et al. Genomics 32(1):121-124(1996)
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