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SUB1 Blocking Peptide(Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P53999 |
|---|---|
| Other Accession | Q4R947, NP_006704.3 |
| Gene ID | 10923 |
|---|---|
| Other Names | Activated RNA polymerase II transcriptional coactivator p15, Positive cofactor 4, PC4, SUB1 homolog, p14, SUB1, PC4, RPO2TC1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 33-47 of HUMAN SUB1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SUB1 |
|---|---|
| Synonyms | PC4, RPO2TC1 |
| Function | General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).
References
Das, C., et al. J. Mol. Biol. 397(1):1-12(2010)
Rajagopalan, S., et al. J. Biol. Chem. 284(32):21728-21737(2009)
Mortusewicz, O., et al. J. Cell Biol. 183(5):769-776(2008)
Batta, K., et al. Mol. Cell. Biol. 27(21):7603-7614(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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