|Other Names||Cystine/glutamate transporter, Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, Solute carrier family 7 member 11, xCT, SLC7A11|
|Target/Specificity||The synthetic peptide sequence is selected from aa 28-42 of HUMAN SLC7A11|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.|
|Cellular Location||Membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
SLC7A11 is a member of a heteromeric Na(+)-independent anionic amino acid transport system highly specific for cystine and glutamate. In this system, designated system Xc(-), the anionic form of cystine is transported in exchange for glutamate.[supplied by OMIM].
D'Angelo, J.A., et al. J. Immunol. 185(6):3217-3226(2010)
Pham, A.N., et al. J. Pharmacol. Exp. Ther. 332(3):949-958(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Lewerenz, J., et al. J. Biol. Chem. 284(2):1106-1115(2009)
Stockhammer, F., et al. Histopathology 54(2):241-247(2009)
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