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ELOVL3 Blocking Peptide(C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9HB03 |
|---|---|
| Other Accession | NP_689523.1 |
| Gene ID | 83401 |
|---|---|
| Other Names | Elongation of very long chain fatty acids protein 3, 3-keto acyl-CoA synthase ELOVL3, Cold-inducible glycoprotein of 30 kDa, ELOVL fatty acid elongase 3, ELOVL FA elongase 3, Very-long-chain 3-oxoacyl-CoA synthase 3, ELOVL3, CIG30 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 256-270 of HUMAN ELOVL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ELOVL3 {ECO:0000255|HAMAP-Rule:MF_03203} |
|---|---|
| Synonyms | CIG30 |
| Function | Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and unsaturated acyl-CoA substrates with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03203, ECO:0000269|PubMed:20937905}; Multi- pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03203} |
| Tissue Location | Testis.. |
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Provided below are standard protocols that you may find useful for product applications.
Background
ELOVL3 plays a role in fatty acid chain elongation and formation of neutral lipids required for skin barrier function (Westerberg et al., 2004 [PubMed 14581464]).
References
Kobayashi, T., et al. FEBS Lett. 581(17):3157-3163(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Westerberg, R., et al. J. Biol. Chem. 279(7):5621-5629(2004)
Monne, M., et al. Eur. J. Biochem. 263(1):264-269(1999)
Lehner, R., et al. Prog. Lipid Res. 35(2):169-201(1996)
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