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UGT2B28 Blocking Peptide(Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9BY64
Other Accession Q8WN97, O77649, O97951, O75795, P54855, O75310, P36537, O02663, P16662, P06133, NP_444267.1
Additional Information
Gene ID 54490
Other Names UDP-glucuronosyltransferase 2B28, UDPGT 2B28, UGT2B28
Target/Specificity The synthetic peptide sequence is selected from aa 233-246 of HUMAN UGT2B28
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UGT2B28 (HGNC:13479)
Function [Isoform 1]: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:11300766). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:11300766). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (androsterone, 3alpha-androstanediol) and estrogens (estradiol, estrone) (PubMed:11300766). Catalyzes the glucuronidation of bile acid substrates, which are natural detergents for dietary lipids absorption (PubMed:11300766). Displays glucuronidation activity toward the phenolic compounds eugenol (PubMed:11300766).
Cellular Location Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm, perinuclear region
Tissue Location Expressed in the liver, breast and kidney.
Research Areas
Citations (0)
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Background

UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

References

Setlur, S.R., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):229-239(2010)
Ross, C.J., et al. Nat. Genet. 41(12):1345-1349(2009)
Menard, V., et al. Hum. Mutat. 30(9):1310-1319(2009)
Levesque, E., et al. Biochemistry 40(13):3869-3881(2001)

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$ 277.78
Cat# BP19881c
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