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UBE2L3 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession P68036
Other Accession P68037, Q3MHP1, NP_003338.1
Additional Information
Gene ID 7332
Other Names Ubiquitin-conjugating enzyme E2 L3, L-UBC, UbcH7, Ubiquitin carrier protein L3, Ubiquitin-conjugating enzyme E2-F1, Ubiquitin-protein ligase L3, UBE2L3, UBCE7, UBCH7
Target/Specificity The synthetic peptide sequence is selected from aa 121-135 of HUMAN UBE2L3
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name UBE2L3
Synonyms UBCE7, UBCH7
Function Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down- regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.
Cellular Location Nucleus. Cytoplasm.
Tissue Location Ubiquitous, with highest expression in testis.
Research Areas
Citations (0)

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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene.


Fransen, K., et al. Hum. Mol. Genet. 19(17):3482-3488(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Purbeck, C., et al. Biochemistry 49(7):1361-1363(2010)
Han, J.W., et al. Nat. Genet. 41(11):1234-1237(2009)

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$ 80.00
$ 99.00
Cat# BP19885b
(40 western blots)
Availability: 2 weeks
Bulk Size
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