|Other Names||C-X-C chemokine receptor type 5, CXC-R5, CXCR-5, Burkitt lymphoma receptor 1, Monocyte-derived receptor 15, MDR-15, CD185, CXCR5, BLR1, MDR15|
|Target/Specificity||The synthetic peptide sequence is selected from aa 15-28 of HUMAN CXCR5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expression in mature B-cells and Burkitt lymphoma cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse conterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Lee, H.T., et al. J. Rheumatol. 37(1):45-52(2010)
El Haibi, C.P., et al. Mol. Cancer 9, 85 (2010) :
Singh, S., et al. Int. J. Cancer 125(10):2288-2295(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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