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CHORDC1 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession Q9UHD1
Other Accession NP_036256.2
Additional Information
Gene ID 26973
Other Names Cysteine and histidine-rich domain-containing protein 1, CHORD domain-containing protein 1, CHORD-containing protein 1, CHP-1, Protein morgana, CHORDC1, CHP1
Target/Specificity The synthetic peptide sequence is selected from aa 142-156 of HUMAN CHORDC1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CHORDC1
Synonyms CHP1
Function Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co- chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755).
Tissue Location Underexpressed in many breast and lung cancers.
Research Areas
Citations (0)
citation

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Background

CHORDC1 may be play a role in the regulation of NOD1 via its interaction with HSP90AA1 (By similarity).

References

Gano, J.J., et al. Mol. Cell Proteomics 9(2):255-270(2010)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Wu, J., et al. FEBS Lett. 579(2):421-426(2005)
Brancaccio, M., et al. FEBS Lett. 551 (1-3), 47-52 (2003) :
Shirasu, K., et al. Cell 99(4):355-366(1999)

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$ 277.78
Cat# BP19911c
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