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BAG1 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q99933
Other Accession NP_004314.4
Additional Information
Gene ID 573
Other Names BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, BAG1, HAP
Target/Specificity The synthetic peptide sequence is selected from aa 118-131 of HUMAN BAG1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BAG1
Synonyms HAP
Function Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
Cellular Location Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria
Tissue Location Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level)
Research Areas
Citations (0)

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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.


Maier, J.V., et al. Biochem. Biophys. Res. Commun. 401(3):406-411(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Sun, N., et al. Am. J. Surg. 200(3):341-345(2010)
Liu, H.Y., et al. Acta Pharmacol. Sin. 30(2):235-241(2009)
Lee, S.S., et al. Exp. Cell Res. 313(15):3222-3238(2007)

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$ 80.00
$ 99.00
Cat# BP19919c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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