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HTRA4 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P83105 |
|---|---|
| Other Accession | NP_710159.1 |
| Gene ID | 203100 |
|---|---|
| Other Names | Serine protease HTRA4, 3421-, High-temperature requirement factor A4, HTRA4 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 298-311 of HUMAN HTRA4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | HTRA4 |
|---|---|
| Function | Serine protease. |
| Cellular Location | Secreted. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
References
Clausen, T., et al. Mol. Cell 10(3):443-455(2002)
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