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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O75844 |
|---|---|
| Other Accession | Q80W54, NP_005848.2 |
| Gene ID | 10269 |
|---|---|
| Other Names | CAAX prenyl protease 1 homolog, Farnesylated proteins-converting enzyme 1, FACE-1, Prenyl protein-specific endoprotease 1, Zinc metalloproteinase Ste24 homolog, ZMPSTE24, FACE1, STE24 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 419-433 of HUMAN ZMPSTE24 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZMPSTE24 |
|---|---|
| Synonyms | FACE1, STE24 |
| Function | Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. |
| Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus inner membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed. High levels in kidney, prostate, testis and ovary |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Miner, J.H. Am. J. Med. Genet. A 152A (8), 2140-2141 (2010) :
Smigiel, R., et al. Am. J. Med. Genet. A 152A (2), 447-452 (2010) :
Fontaine-Bisson, B., et al. J. Mol. Med. 88(2):193-201(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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