|Other Accession||Q2QLE3, Q90YH9, Q2YDE9, NP_690042.1, Q2QLB2, Q09YJ2|
|Other Names||Testin, TESS, TES|
|Target/Specificity||The synthetic peptide sequence is selected from aa 56-70 of HUMAN TES|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.|
|Cellular Location||Cytoplasm. Cell junction, focal adhesion. Note=Detected along actin stress fibers|
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Provided below are standard protocols that you may find useful for product applications.
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. Multiple protein isoforms are encoded by transcript variants of this gene.
Qiu, H., et al. Cancer Sci. 101(5):1255-1260(2010)
Gunduz, E., et al. Arch. Otolaryngol. Head Neck Surg. 135(3):254-260(2009)
Zhong, Y., et al. Mol. Cell. Biochem. 320 (1-2), 85-92 (2009) :
Huang, W., et al. Ai Zheng 27(9):984-988(2008)
Boeda, B., et al. Mol. Cell 28(6):1071-1082(2007)
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