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ADRM1 Blocking Peptide (C-term)

Synthetic peptide

     
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Product Information
Primary Accession Q16186
Other Accession NP_008933.2
Additional Information
Gene ID 11047
Other Names Proteasomal ubiquitin receptor ADRM1, 110 kDa cell membrane glycoprotein, Gp110, Adhesion-regulating molecule 1, ARM-1, Proteasome regulatory particle non-ATPase 13, hRpn13, Rpn13 homolog, ADRM1, GP110
Target/Specificity The synthetic peptide sequence is selected from aa 383-397 of HUMAN ADRM1
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADRM1
Synonyms GP110
Function Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:16815440, PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:18497817, PubMed:24752541, PubMed:25702870, PubMed:25702872). Within the complex, functions as a proteasomal ubiquitin receptor (PubMed:18497817). Engages and activates 19S- associated deubiquitinases UCHL5 and PSMD14 during protein degradation (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541). UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex (PubMed:16906146, PubMed:16990800, PubMed:17139257, PubMed:24752541).
Cellular Location Cytoplasm. Nucleus
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is an integral plasma membrane protein which promotes cell adhesion. The encoded protein is thought to undergo O-linked glycosylation. Expression of this gene has been shown to be induced by gamma interferon in some cancer cells. Two transcript variants encoding the same protein have been found for this gene.

References

Mazumdar, T., et al. Proc. Natl. Acad. Sci. U.S.A. 107(31):13854-13859(2010)
Elangovan, M., et al. Biochem. Biophys. Res. Commun. 396(2):425-428(2010)
Chen, X., et al. Mol. Cell 38(3):404-415(2010)
Kim, T., et al. Biochem. Biophys. Res. Commun. 390(3):585-590(2009)
Chen, W., et al. Zhonghua Zhong Liu Za Zhi 31(11):815-819(2009)

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$ 277.78
Cat# BP19952B
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