|Other Accession||Q4R4T8, NP_005597.3|
|Other Names||Legumain, Asparaginyl endopeptidase, Protease, cysteine 1, LGMN, PRSC1|
|Target/Specificity||The synthetic peptide sequence is selected from aa 98-112 of HUMAN LGMN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.|
|Tissue Location||Ubiquitous. Particularly abundant in kidney, heart and placenta|
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This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform.
Clerin, V., et al. Atherosclerosis 201(1):53-66(2008)
Liu, Z., et al. Mol. Cell 29(6):665-678(2008)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Dusso, A.S., et al. Am. J. Physiol. Renal Physiol. 289 (1), F8-F28 (2005) :
Murthy, R.V., et al. Clin. Cancer Res. 11(6):2293-2299(2005)
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