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SYNJ2 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O15056 |
|---|---|
| Other Accession | NP_003889.1 |
| Gene ID | 8871 |
|---|---|
| Other Names | Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 694-707 of HUMAN SYNJ2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SYNJ2 |
|---|---|
| Synonyms | KIAA0348 |
| Function | Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. |
| Cellular Location | Cytoplasm. Cell membrane. Membrane raft. Presynapse {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at presynapse terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity) Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.
References
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)
Rossi, M.R., et al. Cancer Genet. Cytogenet. 161(2):97-103(2005)
Chuang, Y.Y., et al. Cancer Res. 64(22):8271-8275(2004)
Spaenij-Dekking, E.H., et al. Leukemia 17(12):2467-2473(2003)
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