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SYNJ2 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O15056
Other Accession NP_003889.1
Additional Information
Gene ID 8871
Other Names Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348
Target/Specificity The synthetic peptide sequence is selected from aa 694-707 of HUMAN SYNJ2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNJ2
Synonyms KIAA0348
Function Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Cellular Location Cytoplasm. Cell membrane. Membrane raft. Cell projection, axon {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at nerve terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340)
Research Areas
Citations (0)

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Background

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.

References

Rikova, K., et al. Cell 131(6):1190-1203(2007)
Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)
Rossi, M.R., et al. Cancer Genet. Cytogenet. 161(2):97-103(2005)
Chuang, Y.Y., et al. Cancer Res. 64(22):8271-8275(2004)
Spaenij-Dekking, E.H., et al. Leukemia 17(12):2467-2473(2003)

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$ 80.00
Cat# BP19970c
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