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KCNA4 Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession P22459
Other Accession P15385, Q61423, Q05037, NP_002224.1
Additional Information
Gene ID 3739
Other Names Potassium voltage-gated channel subfamily A member 4, HPCN2, Voltage-gated K(+) channel HuKII, Voltage-gated potassium channel HBK4, Voltage-gated potassium channel HK1, Voltage-gated potassium channel subunit Kv14, KCNA4, KCNA4L
Target/Specificity The synthetic peptide sequence is selected from aa 606-619 of HUMAN KCNA4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNA4
Synonyms KCNA4L
Function Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:19912772, PubMed:8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).
Cellular Location Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:P15385}
Tissue Location Detected in heart ventricle.
Research Areas
Citations (0)

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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.


Schwetz, T.A., et al. Biochim. Biophys. Acta 1798(3):367-375(2010)
Angelova, P.R., et al. Eur. J. Neurosci. 29(10):1943-1950(2009)
Mckeown, L., et al. J. Biol. Chem. 283(44):30421-30432(2008)
Lee, J.H., et al. Mol. Pharmacol. 73(3):619-626(2008)
Gessler, M., et al. Hum. Genet. 90(3):319-321(1992)

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$ 80.00
$ 99.00
Cat# BP19983b
(40 western blots)
Availability: 2 weeks
Bulk Size
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