|Other Names||Hepatitis A virus cellular receptor 2, HAVcr-2, T-cell immunoglobulin and mucin domain-containing protein 3, TIMD-3, T-cell immunoglobulin mucin receptor 3, TIM-3, T-cell membrane protein 3, HAVCR2, TIM3, TIMD3|
|Target/Specificity||The synthetic peptide sequence is selected from aa 182-194 of HUMAN HAVCR2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||T-helper type 1 lymphocyte (Th1)-specific.|
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Provided below are standard protocols that you may find useful for product applications.
CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Cao, B., et al. Cancer Immunol. Immunother. 59(12):1851-1857(2010)
Dorfman, D.M., et al. Hum. Pathol. 41(10):1486-1494(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Dardalhon, V., et al. J. Immunol. 185(3):1383-1392(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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