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PUS10 Blocking Peptide (N-term)

Synthetic peptide

Product Information
Primary Accession Q3MIT2
Other Accession NP_653310.2
Additional Information
Gene ID 150962
Other Names Putative tRNA pseudouridine synthase Pus10, 5499-, Coiled-coil domain-containing protein 139, tRNA pseudouridine 55 synthase, Psi55 synthase, tRNA pseudouridylate synthase, tRNA-uridine isomerase, PUS10, CCDC139, DOBI
Target/Specificity The synthetic peptide sequence is selected from aa 67-78 of HUMAN PUS10
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PUS10
Synonyms CCDC139, DOBI
Function Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.
Research Areas
Citations (0)

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Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM].


Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)
Park, S.Y., et al. BMB Rep 42(8):511-515(2009)

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$ 80.00
$ 99.00
Cat# BP19991a
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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