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SLC2A1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11166 |
|---|---|
| Other Accession | P11167, P13355, P20303, P17809, P46896, P27674, NP_006507.2, P79365 |
| Gene ID | 6513 |
|---|---|
| Other Names | Solute carrier family 2, facilitated glucose transporter member 1, Glucose transporter type 1, erythrocyte/brain, GLUT-1, HepG2 glucose transporter, SLC2A1, GLUT1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 453-464 of HUMAN SLC2A1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC2A1 (HGNC:11005) |
|---|---|
| Function | Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:18245775, PubMed:19449892, PubMed:25982116, PubMed:27078104, PubMed:10227690). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (PubMed:18245775, PubMed:19449892). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (PubMed:10227690). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Melanosome. Photoreceptor inner segment {ECO:0000250|UniProtKB:P17809}. Note=Localizes primarily at the cell surface (PubMed:18245775, PubMed:19449892, PubMed:23219802, PubMed:25982116, PubMed:24847886). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065) |
| Tissue Location | Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a major glucose transporter in the mammalian blood-brain barrier. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia.
References
Mullen, S.A., et al. Neurology 75(5):432-440(2010)
Grabellus, F., et al. J. Nucl. Med. 51(8):1191-1197(2010)
Koda, M., et al. BMC Cancer 10, 320 (2010) :
Kim, S.J., et al. J. Exp. Clin. Cancer Res. 29, 69 (2010) :
Xiong, Y., et al. Eur. J. Gynaecol. Oncol. 31(2):160-164(2010)
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