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PVR Blocking Peptide (C-term)

Synthetic peptide

Product Information
Primary Accession P15151
Other Accession NP_006496.3
Additional Information
Gene ID 5817
Other Names Poliovirus receptor, Nectin-like protein 5, NECL-5, CD155, PVR, PVS
Target/Specificity The synthetic peptide sequence is selected from aa 329-342 of HUMAN PVR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PVR
Synonyms PVS
Function Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Cellular Location Isoform Alpha: Cell membrane; Single-pass type I membrane protein Isoform Beta: Secreted.
Research Areas
Citations (0)

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The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.


Nakai, R., et al. Cancer Sci. 101(5):1326-1330(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Stanietsky, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106(42):17858-17863(2009)
Carlsten, M., et al. J. Immunol. 183(8):4921-4930(2009)
Kindberg, E., et al. J. Med. Virol. 81(5):933-936(2009)

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$ 80.00
$ 99.00
Cat# BP19996b
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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