|Other Accession||P51796, Q9TTU3, Q9GKE7, Q9WVD4, NP_000075.1|
|Other Names||H(+)/Cl(-) exchange transporter 5, Chloride channel protein 5, ClC-5, Chloride transporter ClC-5, CLCN5, CLCK2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 30-41 of HUMAN CLCN5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.|
|Cellular Location||Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Smith, A.J., et al. FASEB J. 24(10):3696-3705(2010)
Wellhauser, L., et al. Pflugers Arch. 460(2):543-557(2010)
Smith, A.J., et al. J. Physiol. (Lond.) 588 (PT 12), 2033-2045 (2010) :
Picollo, A., et al. J. Gen. Physiol. 135(6):653-659(2010)
Reed, A.A., et al. Am. J. Physiol. Renal Physiol. 298 (2), F365-F380 (2010) :
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