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CLCN5 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51795 |
|---|---|
| Other Accession | P51796, Q9TTU3, Q9GKE7, Q9WVD4, NP_000075.1 |
| Gene ID | 1184 |
|---|---|
| Other Names | H(+)/Cl(-) exchange transporter 5, Chloride channel protein 5, ClC-5, Chloride transporter ClC-5, CLCN5, CLCK2 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 30-41 of HUMAN CLCN5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CLCN5 (HGNC:2023) |
|---|---|
| Synonyms | CLCK2 |
| Function | Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
References
Smith, A.J., et al. FASEB J. 24(10):3696-3705(2010)
Wellhauser, L., et al. Pflugers Arch. 460(2):543-557(2010)
Smith, A.J., et al. J. Physiol. (Lond.) 588 (PT 12), 2033-2045 (2010) :
Picollo, A., et al. J. Gen. Physiol. 135(6):653-659(2010)
Reed, A.A., et al. Am. J. Physiol. Renal Physiol. 298 (2), F365-F380 (2010) :
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