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NEU1 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q99519 |
|---|---|
| Other Accession | A6BMK7, NP_000425.1 |
| Gene ID | 4758 |
|---|---|
| Other Names | Sialidase-1, Acetylneuraminyl hydrolase, G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1, NEU1, NANH |
| Target/Specificity | The synthetic peptide sequence is selected from aa 203-214 of HUMAN NEU1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | NEU1 |
|---|---|
| Synonyms | NANH |
| Function | Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. |
| Cellular Location | Lysosome membrane; Peripheral membrane protein; Lumenal side. Lysosome lumen. Cell membrane. Cytoplasmic vesicle Lysosome. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles |
| Tissue Location | Highly expressed in pancreas, followed by skeletal muscle, kidney, placenta, heart, lung and liver. Weakly expressed in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
References
Caciotti, A., et al. J. Neurol. 256(11):1911-1915(2009)
Bonten, E.J., et al. J. Biol. Chem. 284(41):28430-28441(2009)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Wang, J., et al. J. Neurochem. 111(2):547-554(2009)
Lai, S.C., et al. Eur. J. Neurol. 16(8):912-919(2009)
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