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Osteocalcin Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P02818
Other Accession NP_954642
Clone Names 2072405
Peptide ID 2072405
Additional Information
Gene ID 632
Other Names Osteocalcin, Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein, BGLAP
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2002a was selected from the N-term region of human osteocalcin . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Cellular Location Secreted.
Research Areas
Citations (0)

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Prior to the formation of calcified bone, noncollagenous proteins form in the extracellular bone matrix. Gamma-carboxyglutamic acid residues are formed by vitamin K, vitamin-D regulated calcium binding proteins containing residues of Gla. These residues are essential for the binding of calcium and constitue 1-2% of total bone protein. Osteocalcin itself binds strongly to apatite and calcium. Production of osteocalcin is expressed late in normal bone development and is characteristic of mature osteoblasts. Regular osteocalcin production has been shown to be linked to the p53 tumor suppressor gene. The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. The loss of p53 regulation inhibits further osteocalcin production. The absence of end-point differentiation in bone due to p53 rearrangements and lack of osteocalcin production may contribute to the maintenance of the tumorigenic phenotype in osteosarcomas.


Yamada, Y., et al., J. Clin. Endocrinol. Metab. 88(7):3372-3378 (2003).Gronthos, S., et al., J. Bone Miner. Res. 18(4):716-722 (2003).Yousfi, M., et al., Biochem. Biophys. Res. Commun. 297(3):641-644 (2002).Willis, D.M., et al., J. Biol. Chem. 277(40):37280-37291 (2002).Viereck, V., et al., J. Cell. Biochem. 86(2):348-356 (2002).

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$ 80.00
Cat# BP2002a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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