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SF3A2 Blocking Peptide (Center)

Synthetic peptide

Product Information
Primary Accession Q15428
Other Accession Q6AXT8, Q62203, A5PJN8, NP_009096.2
Additional Information
Gene ID 8175
Other Names Splicing factor 3A subunit 2, SF3a66, Spliceosome-associated protein 62, SAP 62, SF3A2, SAP62
Target/Specificity The synthetic peptide sequence is selected from aa 181-194 of HUMAN SF3A2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3A2
Synonyms SAP62
Function Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00130}
Research Areas
Citations (0)

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This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.


Rose, J. Phd, et al. Mol. Med. (2010) In press :
Tanackovic, G., et al. Mol. Biol. Cell 16(3):1366-1377(2005)
Nesic, D., et al. J. Cell. Sci. 117 (PT 19), 4423-4433 (2004) :
Takenaka, K., et al. Biochem. J. 382 (PT 1), 223-230 (2004) :
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)

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$ 80.00
$ 99.00
Cat# BP20040c
(40 western blots)
Availability: 2 weeks
Bulk Size
Seasonal Special on Bulk Order
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