BLVRB Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P30043 |
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Other Accession | NP_000704.1 |
Gene ID | 645 |
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Other Names | Flavin reductase (NADPH), FR, Biliverdin reductase B, BVR-B, Biliverdin-IX beta-reductase, Green heme-binding protein, GHBP, NADPH-dependent diaphorase, NADPH-flavin reductase, FLR, BLVRB, FLR |
Target/Specificity | The synthetic peptide sequence is selected from aa 134-146 of HUMAN BLVRB |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | BLVRB |
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Synonyms | FLR |
Function | Broad specificity oxidoreductase that catalyzes the NADPH- dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. |
Cellular Location | Cytoplasm. |
Tissue Location | Predominantly expressed in liver and erythrocytes. At lower levels in heart, lung, adrenal gland and cerebrum |
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Provided below are standard protocols that you may find useful for product applications.
Background
The final step in heme metabolism in mammals is catalyzed by the cytosolic biliverdin reductase enzymes A and B (EC 1.3.1.24).
References
Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :
Smith, L.J., et al. Biochem. J. 411(3):475-484(2008)
Otterbein, L.E., et al. Trends Immunol. 24(8):449-455(2003)
Wang, J., et al. J. Biol. Chem. 278(22):20069-20076(2003)
Pereira, P.J., et al. Nat. Struct. Biol. 8(3):215-220(2001)
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