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BMPR1A Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P36894
Other Accession NP_004320
Clone Names 2072408
Peptide ID 2072408
Additional Information
Gene ID 657
Other Names Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3
Target/Specificity The synthetic peptide sequence used to generate the antibody AP2004b was selected from the C-term region of human BMPR1A . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ACVRLK3, ALK3
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in skeletal muscle.
Research Areas
Citations (0)

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The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.


Waite, K.A., et al., Hum. Mol. Genet. 12(6):679-684 (2003).Zhou, X.P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001).Astrom, A.K., et al., Mamm. Genome 10(3):299-302 (1999).ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).Ide, H., et al., Cytogenet. Cell Genet. 81 (3-4), 285-286 (1998).

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$ 80.00
Cat# BP2004b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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