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SLC48A1 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6P1K1 |
|---|---|
| Other Accession | B0BNL4, Q9D8M3, NP_060312.2 |
| Gene ID | 55652 |
|---|---|
| Other Names | Heme transporter HRG1, Heme-responsive gene 1 protein homolog, HRG-1, hHRG-1, Solute carrier family 48 member 1, SLC48A1, HRG1 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 128-141 of HUMAN SLC48A1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SLC48A1 (HGNC:26035) |
|---|---|
| Synonyms | HRG1 |
| Function | Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment (PubMed:18418376). In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP) (PubMed:23395172). |
| Cellular Location | Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9D8M3}; Multi-pass membrane protein. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis {ECO:0000250|UniProtKB:Q9D8M3} |
| Tissue Location | Highly expressed in the brain, kidney, heart and skeletal muscle. Moderately expressed in the liver, lung, placenta and small intestine. Strongly expressed in macrophages of the reticuloendothelial system (PubMed:23395172) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
O'Callaghan, K.M., et al. J. Biol. Chem. 285(1):381-391(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Rajagopal, A., et al. Nature 453(7198):1127-1131(2008)
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