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CDKN3 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q16667 |
|---|---|
| Other Accession | NP_005183.2 |
| Gene ID | 1033 |
|---|---|
| Other Names | Cyclin-dependent kinase inhibitor 3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, Cyclin-dependent kinase-interacting protein 2, Kinase-associated phosphatase, CDKN3, CDI1, CIP2, KAP |
| Target/Specificity | The synthetic peptide sequence is selected from aa 54-68 of HUMAN CDKN3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CDKN3 (HGNC:1791) |
|---|---|
| Synonyms | CDI1, CIP2, KAP |
| Function | May play a role in cell cycle regulation. Dual specificity CC phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues (PubMed:8127873, PubMed:8242750). Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner (PubMed:7569954). |
| Cellular Location | Cytoplasm, perinuclear region |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
References
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Jiang, R., et al. Int. J. Cancer 126(5):1263-1274(2010)
Okamoto, K., et al. Biochem. Biophys. Res. Commun. 351(1):216-222(2006)
Hsieh, M.J., et al. Biochem. Biophys. Res. Commun. 349(2):573-581(2006)
Chinami, M., et al. J. Biol. Chem. 280(17):17235-17242(2005)
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