UCHL5 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y5K5 |
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Other Accession | NP_057068.1 |
Gene ID | 51377 |
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Other Names | Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5, UCHL5, UCH37 |
Target/Specificity | The synthetic peptide sequence is selected from aa 151-164 of HUMAN UCHL5 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | UCHL5 |
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Synonyms | UCH37 |
Function | Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1. |
Cellular Location | Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.
References
Nishio, K., et al. Biochem. Biophys. Res. Commun. 390(3):855-860(2009)
Yao, T., et al. Mol. Cell 31(6):909-917(2008)
Koulich, E., et al. Mol. Biol. Cell 19(3):1072-1082(2008)
Qiu, X.B., et al. EMBO J. 25(24):5742-5753(2006)
Hamazaki, J., et al. EMBO J. 25(19):4524-4536(2006)
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