|Other Names||Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5, UCHL5, UCH37|
|Target/Specificity||The synthetic peptide sequence is selected from aa 151-164 of HUMAN UCHL5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.|
|Cellular Location||Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome.
Nishio, K., et al. Biochem. Biophys. Res. Commun. 390(3):855-860(2009)
Yao, T., et al. Mol. Cell 31(6):909-917(2008)
Koulich, E., et al. Mol. Biol. Cell 19(3):1072-1082(2008)
Qiu, X.B., et al. EMBO J. 25(24):5742-5753(2006)
Hamazaki, J., et al. EMBO J. 25(19):4524-4536(2006)
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