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Mouse Mavs Blocking Peptide (N-term)

Synthetic peptide

     
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Product Information
Primary Accession Q8VCF0
Other Accession NP_659137.1
Additional Information
Gene ID 228607
Other Names Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Virus-induced-signaling adapter, VISA, Mavs, Ips1, Visa
Target/Specificity The synthetic peptide sequence is selected from aa 5-18 of MOUSE Mavs
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name Mavs
Synonyms Ips1, Visa
Function Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).
Cellular Location Mitochondrion outer membrane. Mitochondrion. Peroxisome
Research Areas
Citations (0)

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Background

Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis (By similarity).

References

Ichinohe, T., et al. Nat. Immunol. 11(5):404-410(2010)
DeWitte-Orr, S.J., et al. PLoS Pathog. 6 (3), E1000829 (2010) :
Suthar, M.S., et al. PLoS Pathog. 6 (2), E1000757 (2010) :
Dong, X., et al. PLoS Pathog. 6 (7), E1001001 (2010) :
Faul, E.J., et al. PLoS Pathog. 6 (7), E1001016 (2010) :

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$ 80.00
$ 99.00
Cat# BP20074a
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