DIRC2 Blocking Peptide (Center)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q96SL1 |
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Other Accession | Q8BFQ6, NP_116228.1 |
Gene ID | 84925 |
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Other Names | Disrupted in renal carcinoma protein 2, Disrupted in renal cancer protein 2, DIRC2 |
Target/Specificity | The synthetic peptide sequence is selected from aa 217-229 of HUMAN DIRC2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | SLC49A4 (HGNC:16628) |
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Function | Mediates H(+)-dependent pyridoxine transport. |
Cellular Location | Lysosome membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous. Expressed in proximal tubular cells of the kidney. Highly expressed in the placenta, brain and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined.
References
Bodmer, D., et al. Cancer Genet. Cytogenet. 136(2):95-100(2002)
Bodmer, D., et al. Hum. Mol. Genet. 11(6):641-649(2002)
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