|Other Accession||Q8BFQ6, NP_116228.1|
|Other Names||Disrupted in renal carcinoma protein 2, Disrupted in renal cancer protein 2, DIRC2|
|Target/Specificity||The synthetic peptide sequence is selected from aa 217-229 of HUMAN DIRC2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Electrogenic metabolite transporter.|
|Cellular Location||Lysosome membrane; Multi-pass membrane protein|
|Tissue Location||Ubiquitous. Expressed in proximal tubular cells of the kidney.|
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This gene encodes a membrane-bound protein from the major facilitator superfamily of transporters. Disruption of this gene by translocation has been associated with haplo-insufficiency and renal cell carcinomas. Alternatively spliced transcript variants have been described, but their biological validity has not yet been determined.
Bodmer, D., et al. Cancer Genet. Cytogenet. 136(2):95-100(2002)
Bodmer, D., et al. Hum. Mol. Genet. 11(6):641-649(2002)
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