GLUD2 Blocking Peptide (N-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P49448 |
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Other Accession | NP_036216.2 |
Gene ID | 2747 |
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Other Names | Glutamate dehydrogenase 2, mitochondrial, GDH 2, GLUD2, GLUDP1 |
Target/Specificity | The synthetic peptide sequence is selected from aa 90-103 of HUMAN GLUD2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GLUD2 |
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Synonyms | GLUDP1 |
Function | Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. |
Cellular Location | Mitochondrion matrix |
Tissue Location | Expressed in retina, testis and, at a lower level, brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.
References
Spanaki, C., et al. J. Biol. Chem. 285(22):16748-16756(2010)
Plaitakis, A., et al. Eur. J. Hum. Genet. 18(3):336-341(2010)
Zaganas, I., et al. Neurochem. Int. 55 (1-3), 52-63 (2009) :
Mastorodemos, V., et al. Biochem. Cell Biol. 87(3):505-516(2009)
Kanavouras, K., et al. J. Neurochem. 109 SUPPL 1, 167-173 (2009) :
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