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KRT86 Blocking Peptide (Center)

Synthetic peptide

     
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Product Information
Primary Accession O43790
Other Accession Q9Z2T6, P78386, P78385, A4FUZ0, Q14533, Q148H4, A6NCN2, NP_002275.1, P15241, P25691
Additional Information
Gene ID 3892
Other Names Keratin, type II cuticular Hb6, Hair keratin K211, Keratin-86, K86, Type II hair keratin Hb6, Type-II keratin Kb26, KRT86, KRTHB6
Target/Specificity The synthetic peptide sequence is selected from aa 315-327 of HUMAN KRT86
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KRT86
Synonyms KRTHB6
Tissue Location Synthesis begins slightly higher in the hair shaft than HB1 and HB3 and continues much farther up, ending in the keratogeneous zone.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.

References

ZHANG, S.D., et al. Eur J Dermatol 19(5):508-509(2009)
Feng, A.P., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25(2):141-144(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)
Langbein, L., et al. Int. Rev. Cytol. 243, 1-78 (2005) :

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$ 277.78
Cat# BP20108c
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