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FCSD2 Blocking Peptide (C-term)
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O94868 |
|---|---|
| Other Accession | NP_055639.2 |
| Gene ID | 9873 |
|---|---|
| Other Names | FCH and double SH3 domains protein 2, Carom, SH3 multiple domains protein 3, FCHSD2, KIAA0769, SH3MD3 |
| Target/Specificity | The synthetic peptide sequence is selected from aa 721-734 of HUMAN FCHSD2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FCHSD2 |
|---|---|
| Synonyms | KIAA0769, SH3MD3 |
| Function | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to- late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380) Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). |
| Tissue Location | Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein is unknown.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Thalappilly, S., et al. Proteomics 8(15):3071-3081(2008)
Taylor, T.D., et al. Nature 440(7083):497-500(2006)
Katoh, M., et al. Int. J. Mol. Med. 13(5):749-754(2004)
Coyle, I.P., et al. Neuron 41(4):521-534(2004)
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